Neuroendocrine subtypes of small cell lung cancer differ in terms of immune microenvironment and checkpoint molecule distribution

Neuroendocrine subtypes of small cell lung cancer differ in terms of immune microenvironment and checkpoint molecule distribution

Small cell lung cancer (SCLC) has recently been subcategorized into neuroendocrine (NE)‐high and NE‐low subtypes showing ‘immune desert’ and ‘immune oasis’ phenotypes, respectively. Here, we aimed to characterize the tumor microenvironment according to immune checkpoints and NE subtypes in human SCL...

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Bibliographic Details
Main Authors: David Dora, Christopher Rivard, Hui Yu, Paul Bunn, Kenichi Suda, Shengxiang Ren, Shivaun Lueke Pickard, Viktoria Laszlo, Tunde Harko, Zsolt Megyesfalvi, Judit Moldvay, Fred R. Hirsch, Balazs Dome, Zoltan Lohinai
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Molecular Oncology
Subjects:
neuroendocrine
proteomics
SCLC
tumor microenvironment
tumor‐infiltrating immune cells
Online Access:https://doi.org/10.1002/1878-0261.12741

Internet

https://doi.org/10.1002/1878-0261.12741

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