Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer’s Disease Brain

Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer’s Disease Brain

The R47H variant in the microglial triggering receptor expressed on myeloid cell 2 (TREM2) receptor is a strong risk factor for Alzheimer’s disease (AD). To characterize processes affected by R47H, we performed an integrative network analysis of genes expressed in brains of AD patients with R47H, sp...

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Bibliographic Details
Main Authors: Olena Korvatska, Kostantin Kiianitsa, Alexander Ratushny, Mark Matsushita, Neal Beeman, Wei-Ming Chien, Jun-Ichi Satoh, Michael O. Dorschner, C. Dirk Keene, Theo K. Bammler, Thomas D. Bird, Wendy H. Raskind
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
microglia
neurodegeneration
aging
inflammation
interferon type I response
NKG2D ligands
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.559342/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.559342/full

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