Anticytomegalovirus Peptides Point to New Insights for CMV Entry Mechanisms and the Limitations of In Vitro Screenings

Anticytomegalovirus Peptides Point to New Insights for CMV Entry Mechanisms and the Limitations of In Vitro Screenings

In the absence of an effective vaccine to prevent HCMV infections, alternative interventions must be developed. Prevention of viral entry into susceptible cells is an attractive alternative strategy. Here we report that heparan sulfate-binding peptides effectively inhibit entry into fibroblasts of i...

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Bibliographic Details
Main Authors: Joseph W. Jackson, Trevor J. Hancock, Pranay Dogra, Ravi Patel, Ravit Arav-Boger, Angela D. Williams, Stephen J. Kennel, Jonathan S. Wall, Tim E. Sparer
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mSphere
Subjects:
HCMV
MCMV
antiviral peptides
cytomegalovirus
entry
heparan sulfate
Online Access:https://doi.org/10.1128/mSphere.00586-18

Internet

https://doi.org/10.1128/mSphere.00586-18

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