Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway

Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway

The purpose of the current study was to investigate whether peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) can interact with calpastatin (CAST) and regulate CAST/calpain2, under excessive glutamate conditions, and subsequently regulate necrosis in rat retinal neurons. Glutamate trigge...

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Bibliographic Details
Main Authors: Shuchao Wang, Lvshuang Liao, Mi Wang, Hongkang Zhou, Yanxia Huang, Zhen Wang, Dan Chen, Dan Ji, Xiaobo Xia, Yong Wang, Fengxia Liu, Jufang Huang, Kun Xiong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
glutamate
regulated necrosis
calpain2
calpastatin
Pin1
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00425/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00425/full

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