Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes

Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes

Abstract Background CCHCR1 (Coiled-Coil α-Helical Rod protein 1) is a putative psoriasis candidate gene with the risk alleles CCHCR1*WWCC and *Iso3, the latter inhibiting the translation of isoform 1. CCHCR1 was recently shown to be a centrosomal protein, as well as a component of cytoplasmic proces...

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Bibliographic Details
Main Authors: Mari H. Tervaniemi, Shintaro Katayama, Tiina Skoog, H. Annika Siitonen, Jyrki Vuola, Kristo Nuutila, Kristiina Tammimies, Sari Suomela, Esko Kankuri, Juha Kere, Outi Elomaa
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Genomics
Subjects:
CCHCR1
PSORS1
Centrosome
Cytoskeleton
P-body
Cell adhesion
Online Access:http://link.springer.com/article/10.1186/s12864-018-4810-y

Internet

http://link.springer.com/article/10.1186/s12864-018-4810-y

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