Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling.

The role of neo-angiogenesis in prostate cancer (PCA) growth and metastasis is well established, but the development of effective and non-toxic pharmacological inhibitors of angiogenesis remains an unaccomplished goal. In this regard, targeting aberrant angiogenesis through non-toxic phytochemicals...

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Bibliographic Details
Main Authors: Gagan Deep, Subhash Chander Gangar, Subapriya Rajamanickam, Komal Raina, Mallikarjuna Gu, Chapla Agarwal, Nicholas H Oberlies, Rajesh Agarwal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3326063?pdf=render