Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008

Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008

Abstract Background Drug resistance of B-cell precursor acute lymphoblastic leukemia (BP-ALL) cells is conferred by both intrinsic and extrinsic factors, which could be targeted to promote chemo-sensitization. Our previous studies showed that Galectin-3, a lectin that clusters galactose-modified gly...

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Bibliographic Details
Main Authors: Helicia Paz, Eun Ji Joo, Chih-Hsing Chou, Fei Fei, Kevin H. Mayo, Hisham Abdel-Azim, Haike Ghazarian, John Groffen, Nora Heisterkamp
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lymphoid neoplasia
Co-culture
Stroma
Migration
Adhesion
Online Access:http://link.springer.com/article/10.1186/s13046-018-0721-7

Internet

http://link.springer.com/article/10.1186/s13046-018-0721-7

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