Soluble fibrinogen-like protein 2 promotes the growth of hepatocellular carcinoma via attenuating dendritic cell-mediated cytotoxic T cell activity

Soluble fibrinogen-like protein 2 promotes the growth of hepatocellular carcinoma via attenuating dendritic cell-mediated cytotoxic T cell activity

Abstract Background Soluble fibrinogen-like protein 2 (sFGL2), a secretory protein expressed by regulatory T cells (Tregs) with immunosuppressive activity, is highly expressed in both the peripheral blood and tumor tissue of patients with hepatocellular carcinoma (HCC); however, sFGL2 function in HC...

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Bibliographic Details
Main Authors: Muyang Yang, Zhongwei Zhang, Jiajia Chen, Mengying Xu, Jiaquan Huang, Ming Wang, Weina Li, Xiaoyang Wan, Man-Fung Yuen, Xiaoping Luo, Dong Xi, Qin Ning
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Soluble fibrinogen-like protein 2
Hepatocellular carcinoma
Tumor microenvironment
Dendritic cells
Immunosuppression
Online Access:http://link.springer.com/article/10.1186/s13046-019-1326-5

Internet

http://link.springer.com/article/10.1186/s13046-019-1326-5

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