Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity

Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity

Objective: Glucagon-like peptides are co-released from enteroendocrine L cells in the gut and preproglucagon (PPG) neurons in the brainstem. PPG-derived GLP-1/2 are probably key neuroendocrine signals for the control of energy balance and glucose homeostasis. The objective of this study was to deter...

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Bibliographic Details
Main Authors: Xuemei Shi, Shaji Chacko, Feng Li, Depei Li, Douglas Burrin, Lawrence Chan, Xinfu Guan
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Molecular Metabolism
Subjects:
Preproglucagon neurons
Glucagon-like peptides
Glucagon-Cre mice
Insulin sensitivity
Endogenous glucose production
Gluconeogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817305495

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http://www.sciencedirect.com/science/article/pii/S2212877817305495

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