TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat

TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat

Abstract Background Accurate and sensitive imaging biomarkers are required to study the progression of white matter (WM) inflammation in neurodegenerative diseases. Radioligands targeting the translocator protein (TSPO) are considered sensitive indicators of neuroinflammation, but it is not clear ho...

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Bibliographic Details
Main Authors: Nassir U. Al-Khishman, Qi Qi, Austyn D. Roseborough, Alexander Levit, Brian L. Allman, Udunna C. Anazodo, Matthew S. Fox, Shawn N. Whitehead, Jonathan D. Thiessen
Format: Article
Language:English
Published: SpringerOpen 2020-09-01
Series:EJNMMI Research
Subjects:
TSPO
Major histocompatibility complex class II
White matter inflammation
Ischemic stroke
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13550-020-00699-x

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http://link.springer.com/article/10.1186/s13550-020-00699-x

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