Rituximab-specific DNA aptamers are able to selectively recognize heat-treated antibodies.

The monoclonal anti-CD20 IgG1 antibody rituximab is used as a first-line treatment for B cell lymphoma. Like all therapeutic antibodies, it is a complex protein for which both safety and efficacy heavily depend on the integrity of its three-dimensional structure. Aptamers, short oligonucleotides wit...

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Bibliographic Details
Main Authors: Michael Kohlberger, Sabrina Wildner, Christof Regl, Christian G Huber, Gabriele Gadermaier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0241560