Expanding metabolic engineering algorithms using feasible space and shadow price constraint modules

While numerous computational methods have been developed that use genome-scale models to propose mutants for the purpose of metabolic engineering, they generally compare mutants based on a single criteria (e.g., production rate at a mutant׳s maximum growth rate). As such, these approaches remain lim...

Full description

Bibliographic Details
Main Authors: Christopher J. Tervo, Jennifer L. Reed
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Metabolic Engineering Communications
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030114000029