Iron Regulatory Proteins Control a Mucosal Block to Intestinal Iron Absorption

Iron Regulatory Proteins Control a Mucosal Block to Intestinal Iron Absorption

Mammalian iron metabolism is regulated systemically by the hormone hepcidin and cellularly by iron regulatory proteins (IRPs) that orchestrate a posttranscriptional regulatory network. Through ligand-inducible genetic ablation of both IRPs in the gut epithelium of adult mice, we demonstrate that IR...

Full description

Bibliographic Details
Main Authors: Bruno Galy, Dunja Ferring-Appel, Christiane Becker, Norbert Gretz, Hermann-Josef Gröne, Klaus Schümann, Matthias W. Hentze
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713001022

Internet

http://www.sciencedirect.com/science/article/pii/S2211124713001022

Similar Items