Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

Abstract Background Blood–brain barrier (BBB) breakdown and inflammation are critical events in ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of microvascular endothelial cells sealed by tight junctions to protect the brain from blood-borne substances. Thus, the m...

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Bibliographic Details
Main Authors: Haiying Zhang, Joon Ha Park, Sony Maharjan, Jeong Ae Park, Kyu-Sung Choi, Hyojin Park, Yoonjeong Jeong, Ji Hyeon Ahn, In Hye Kim, Jae-Chul Lee, Jeong Hwi Cho, In-Kyu Lee, Choong Hyun Lee, In Koo Hwang, Young-Myeong Kim, Young-Ger Suh, Moo-Ho Won, Young-Guen Kwon
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Neuroinflammation
Subjects:
Sac-1004
Cerebral ischemia
Blood–brain barrier
Tight junction
Inflammation
Neuroprotection
Online Access:http://link.springer.com/article/10.1186/s12974-017-0897-3

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http://link.springer.com/article/10.1186/s12974-017-0897-3

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