Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency

Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency

Neonatal epileptic encephalopathy (NEE), as a result of pyridoxine 5′-phosphate oxidase (PNPO) deficiency, is a rare neural disorder characterized by intractable seizures and usually leads to early infant death. The clinical phenotypes do not respond to antiepileptic drugs but are alleviated in most...

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Bibliographic Details
Main Authors: Po-Yuan Chen, Hung-Chi Tu, Verne Schirch, Martin K. Safo, Tzu-Fun Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
pyridoxal 5′-phosphate (PLP)-dependent neonatal epileptic encephalopathy
pyridoxine 5′-phosphate oxidase
pyridoxamine
zebrafish
animal model
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01086/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01086/full

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