Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids

Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids

Abstract Background Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previously reported human pancreas organoid (hPO) cultures do not expand effi...

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Bibliographic Details
Main Authors: Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J. Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D. Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy, Meritxell Huch
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Developmental Biology
Subjects:
Pancreas
Organoid
In vivo safety
Chemically defined hydrogel
Genetic stability
Primary cultures
Online Access:http://link.springer.com/article/10.1186/s12861-020-0209-5

Internet

http://link.springer.com/article/10.1186/s12861-020-0209-5

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