Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action

Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action

Summary: DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining (NHEJ) or homologous recombination (HR). RIF1 negatively regulates resection through the effector Shieldin, which associates with a short 3′ single-stranded DNA (ssDNA) overhang by the MRN (MRE11-RAD50-NBS1) c...

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Bibliographic Details
Main Authors: Shin-Ya Isobe, Shin-ichiro Hiraga, Koji Nagao, Hiroyuki Sasanuma, Anne D. Donaldson, Chikashi Obuse
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
RIF1
PP1
Resection
Shieldin
NHEJ
HR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007816

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http://www.sciencedirect.com/science/article/pii/S2211124721007816

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