Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis

Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis

Firing activity of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) is controlled by inhibitory somatodendritic 5-HT1A autoreceptors. This autoinhibitory mechanism is implicated in the etiology of disorders of emotion regulation, such as anxiety disorders and depression, as well as in the...

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Bibliographic Details
Main Authors: Naozumi eAraragi, Boris eMlinar, Gilda eBaccini, Lise eGutknecht, Klaus-Peter eLesch, Renato eCorradetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Pharmacology
Subjects:
dorsal raphe nucleus
serotonin transporter
5-HT1A receptor
autoinhibition
knockout
tryptophan hydroxylase-2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00097/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00097/full

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