Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development

Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development

Summary: The neural crest (NC) gives rise to a multitude of fetal tissues, and its misregulation is implicated in congenital malformations. Here, we investigated molecular mechanisms pertaining to NC-related symptoms in Bohring-Opitz syndrome (BOS), a developmental disorder linked to mutations in th...

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Main Authors: Friederike Matheus, Ejona Rusha, Rizwan Rehimi, Lena Molitor, Anna Pertek, Miha Modic, Regina Feederle, Andrew Flatley, Elisabeth Kremmer, Arie Geerlof, Valentyna Rishko, Alvaro Rada-Iglesias, Micha Drukker
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119300918

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http://www.sciencedirect.com/science/article/pii/S2213671119300918

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