Comparative transcriptional network modeling of three PPAR-α/γ co-agonists reveals distinct metabolic gene signatures in primary human hepatocytes.

Comparative transcriptional network modeling of three PPAR-α/γ co-agonists reveals distinct metabolic gene signatures in primary human hepatocytes.

To compare the molecular and biologic signatures of a balanced dual peroxisome proliferator-activated receptor (PPAR)-α/γ agonist, aleglitazar, with tesaglitazar (a dual PPAR-α/γ agonist) or a combination of pioglitazone (Pio; PPAR-γ agonist) and fenofibrate (Feno; PPAR-α agonist) in human hepatocyt...

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Bibliographic Details
Main Authors: Renée Deehan, Pia Maerz-Weiss, Natalie L Catlett, Guido Steiner, Ben Wong, Matthew B Wright, Gil Blander, Keith O Elliston, William Ladd, Maria Bobadilla, Jacques Mizrahi, Carolina Haefliger, Alan Edgar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3325914?pdf=render

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http://europepmc.org/articles/PMC3325914?pdf=render

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