Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

CRISPR-Cas systems protect bacteria and archaea from phages and other mobile genetic elements, which use small anti-CRISPR (Acr) proteins to overcome CRISPR-Cas immunity. Because Acrs are challenging to identify, their natural diversity and impact on microbial ecosystems are underappreciated. To ove...

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Bibliographic Details
Main Authors: Kevin J Forsberg, Ishan V Bhatt, Danica T Schmidtke, Kamyab Javanmardi, Kaylee E Dillard, Barry L Stoddard, Ilya J Finkelstein, Brett K Kaiser, Harmit S Malik
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
CRISPR-Cas
anti-CRISPR
functional metagenomics
human microbiome
phage
bacterial defense systems
Online Access:https://elifesciences.org/articles/46540

Internet

https://elifesciences.org/articles/46540

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