Are In Vitro Human Blood–Brain–Tumor-Barriers Suitable Replacements for In Vivo Models of Brain Permeability for Novel Therapeutics?

Are In Vitro Human Blood–Brain–Tumor-Barriers Suitable Replacements for In Vivo Models of Brain Permeability for Novel Therapeutics?

Background: High grade gliomas (HGG) are incapacitating and prematurely fatal diseases. To overcome the poor prognosis, novel therapies must overcome the selective and restricted permeability of the blood–brain barrier (BBB). This study critically evaluated whether in vitro human normal BBB and tumo...

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Bibliographic Details
Main Authors: Archana Prashanth, Heather Donaghy, Shihani P. Stoner, Amanda L. Hudson, Helen R. Wheeler, Connie I. Diakos, Viive M. Howell, Georges E. Grau, Kelly J. McKelvey
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
blood brain barrier
permeability
neurovascular unit
brain microvascular endothelial cells
induced pluripotent stem cells
tight junctions
Online Access:https://www.mdpi.com/2072-6694/13/5/955

Internet

https://www.mdpi.com/2072-6694/13/5/955

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