AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear

Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even so, there are few AAV capsids that transduce both inner and outer hair cells—the cells that express most deafness genes—and fewe...

Full description

Bibliographic Details
Main Authors:	Maryna V. Ivanchenko, Killian S. Hanlon, Daniel M. Hathaway, Alex J. Klein, Cole W. Peters, Yaqiao Li, Panos I. Tamvakologos, Josette Nammour, Casey A. Maguire, David P. Corey
Format:	Article
Language:	English
Published:	Elsevier 2021-06-01
Series:	Molecular Therapy: Methods & Clinical Development
Subjects:	inner ear adeno-associated virus vector non-human primate cochlea hair cells hereditary deafness
Online Access:	http://www.sciencedirect.com/science/article/pii/S2329050121000590

Internet

http://www.sciencedirect.com/science/article/pii/S2329050121000590

AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear

Internet

Similar Items