Overexpression of miR-124 in Motor Neurons Plays a Key Role in ALS Pathological Processes

Overexpression of miR-124 in Motor Neurons Plays a Key Role in ALS Pathological Processes

miRNA(miR)-124 is an important regulator of neurogenesis, but its upregulation in SOD1G93A motor neurons (mSOD1 MNs) was shown to associate with neurodegeneration and microglia activation. We used pre-miR-124 in wild-type (WT) MNs and anti-miR-124 in mSOD1 MNs to characterize the miR-124 pathologica...

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Bibliographic Details
Main Authors: Ana Rita Vaz, Daniela Vizinha, Hermes Morais, Ana Rita Colaço, Gecioni Loch-Neckel, Marta Barbosa, Dora Brites
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
inflamma-miRNAs
miR-124 modulation
motor neuron regeneration
motor neuron secretome
mSOD1 mice model
Online Access:https://www.mdpi.com/1422-0067/22/11/6128

Internet

https://www.mdpi.com/1422-0067/22/11/6128

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