Hesperidin alleviates insulin resistance by improving HG-induced oxidative stress and mitochondrial dysfunction by restoring miR-149

Abstract Background Hesperidin, a natural flavanone, has been proven to have multiple protective effects in diabetic rats, such as antioxidant, anti-inflammatory and anti-apoptotic effects. However, the molecular mechanisms underlying the effects of hesperidin are not well elucidated. Methods LO2 ce...

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Bibliographic Details
Main Authors: Miao Tian, Yu-Bo Han, Cheng-Cheng Zhao, Li Liu, Fu-Li Zhang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Online Access:https://doi.org/10.1186/s13098-021-00664-1