Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

Abstract Background The sexual stages of Plasmodium falciparum are responsible for the spread of the parasite in malaria endemic areas. The cysteine-rich Pfs48/45 protein, exposed on the surface of sexual stages, is one of the most advanced antigens for inclusion into a vaccine that will block trans...

Full description

Bibliographic Details
Main Authors: Susheel K. Singh, Will Roeffen, Ulrik H. Mistarz, Bishwanath Kumar Chourasia, Fen Yang, Kasper D. Rand, Robert W. Sauerwein, Michael Theisen
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Microbial Cell Factories
Subjects:
Plasmodium falciparum
Malaria
Transmission blocking
Pfs48/45
Batch fermentation and Lactococcus lactis
Online Access:http://link.springer.com/article/10.1186/s12934-017-0710-0

Internet

http://link.springer.com/article/10.1186/s12934-017-0710-0

Similar Items