Apolipoprotein E3 Inhibits Rho to Regulate the Mechanosensitive Expression of Cox2.

Apolipoprotein E3 (apoE3) is thought to protect against atherosclerosis by enhancing reverse cholesterol transport. However, apoE3 also has cholesterol-independent effects that contribute to its anti-atherogenic properties. These include altering extracellular matrix protein synthesis and inhibiting...

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Bibliographic Details
Main Authors: Bernadette Y Hsu, Yong Ho Bae, Keeley L Mui, Shu-Lin Liu, Richard K Assoian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4465925?pdf=render