Synthesis and pharmacological evaluation of several N-(2-nitrophenyl) piperazine derivatives

Synthesis and pharmacological evaluation of several N-(2-nitrophenyl) piperazine derivatives

Six newly synthesized heterocyclic (2-nitrophenyl)piperazines, with a specific structure of the heteroaryl group, whichmimics the catechol moiety of dopamine (benzimidazoles and substituted benzimidazoles), were evaluated for their binding affinity to rat dopamine (DA), serotonin (5-HT) and _1 recep...

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Bibliographic Details
Main Authors: Andrić Deana, Tovilović Gordana, Roglić Goran, Vasković Đurđica, Šoškić Vukić, Tomić Mirko, Kostić-Rajačić Slađana
Format: Article
Language:English
Published: Serbian Chemical Society 2007-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
arylpiperazines
benzimidazoles
dopamine receptors
serotonin receptors
atypical antipsychotic
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2007/0352-51390705429A.pdf

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http://www.doiserbia.nb.rs/img/doi/0352-5139/2007/0352-51390705429A.pdf

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