A regulatory polymorphism in HAVCR2 modulates susceptibility to HIV-1 infection.

A regulatory polymorphism in HAVCR2 modulates susceptibility to HIV-1 infection.

The HAVCR2 gene encodes TIM-3, an immunoglobulin superfamily member expressed by exhausted CD8+ T cells during chronic viral infection. We investigated whether genetic variation at HAVCR2 modulates the susceptibility to HIV-1 acquisition; specifically we focused on a 3' UTR variant (rs4704846,...

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Bibliographic Details
Main Authors: Manuela Sironi, Mara Biasin, Federica Gnudi, Rachele Cagliani, Irma Saulle, Diego Forni, Veronica Rainone, Daria Trabattoni, Micaela Garziano, Francesco Mazzotta, Luis Miguel Real, Antonio Rivero-Juarez, Antonio Caruz, Sergio Lo Caputo, Mario Clerici
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4152274?pdf=render

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http://europepmc.org/articles/PMC4152274?pdf=render

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