NLRR1 Is a Potential Therapeutic Target in Neuroblastoma and MYCN-Driven Malignant Cancers

NLRR1 Is a Potential Therapeutic Target in Neuroblastoma and MYCN-Driven Malignant Cancers

Receptor tyrosine kinases (RTKs) receive different modulation before transmitting proliferative signals. We previously identified neuronal leucine-rich repeat 1 (NLRR1) as a positive regulator of EGF and IGF-1 signals in high-risk neuroblastoma cells. Here, we show that NLRR1 is up-regulated in vari...

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Bibliographic Details
Main Authors: Atsushi Takatori, MD. Shamim Hossain, Atsushi Ogura, Jesmin Akter, Yohko Nakamura, Akira Nakagawara
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
neuronal leucine-rich repeat 1
neuroblastoma
epidermal growth factor receptor
monoclonal antibody
epitope mapping
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.669667/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.669667/full

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