HCV Defective Genomes Promote Persistent Infection by Modulating the Viral Life Cycle

HCV Defective Genomes Promote Persistent Infection by Modulating the Viral Life Cycle

Defective interfering (DI) RNAs have been detected in several human viruses. HCV in-frame deletions mutants (IFDMs), missing mainly the envelope proteins, have been found in patient sera and liver tissues. IFDMs replicate independently and can be trans-packaged into infectious virions in the presenc...

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Bibliographic Details
Main Authors: Eirini Karamichali, Hajar Chihab, Athanassios Kakkanas, Agnes Marchio, Timokratis Karamitros, Vasiliki Pogka, Agoritsa Varaklioti, Antonis Kalliaropoulos, Beatrice Martinez-Gonzales, Pelagia Foka, Ioannis Koskinas, Andreas Mentis, Soumaya Benjelloun, Pascal Pineau, Urania Georgopoulou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
hepatitis C
defective genomes
exosomes
viral replication
viral persistence
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02942/full

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02942/full

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