A Multi-Study Model-Based Evaluation of the Sequence of Imaging and Clinical Biomarker Changes in Huntington’s Disease

A Multi-Study Model-Based Evaluation of the Sequence of Imaging and Clinical Biomarker Changes in Huntington’s Disease

Understanding the order and progression of change in biomarkers of neurodegeneration is essential to detect the effects of pharmacological interventions on these biomarkers. In Huntington’s disease (HD), motor, cognitive and MRI biomarkers are currently used in clinical trials of drug efficacy. Here...

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Bibliographic Details
Main Authors: Peter A. Wijeratne, Eileanoir B. Johnson, Sarah Gregory, Nellie Georgiou-Karistianis, Jane S. Paulsen, Rachael I. Scahill, Sarah J. Tabrizi, Daniel C. Alexander
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Big Data
Subjects:
huntington’s disease
biomarkers
disease progression model
multi-study investigation
clinical staging
Online Access:https://www.frontiersin.org/articles/10.3389/fdata.2021.662200/full

Internet

https://www.frontiersin.org/articles/10.3389/fdata.2021.662200/full

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