ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels

ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels

Nerve growth factor (NGF) promotes the survival and differentiation of neurons. NGF is initially synthesized as a precursor, proNGF, which is the predominant form in the central nervous system. NGF and proNGF bind to TrkA/p75NTR to mediate cell survival and to sortilin/p75NTR to promote apoptosis. T...

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Bibliographic Details
Main Authors: Maria S. Ioannou, Margaret Fahnestock
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:International Journal of Molecular Sciences
Subjects:
neurotrophin
proNGF
TrkA
p75NTR
sortilin
PC12 cells
apoptosis
Online Access:http://www.mdpi.com/1422-0067/18/3/599

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http://www.mdpi.com/1422-0067/18/3/599

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