Cleavage activates Dispatched for Sonic Hedgehog ligand release

Cleavage activates Dispatched for Sonic Hedgehog ligand release

Hedgehog ligands activate an evolutionarily conserved signaling pathway that provides instructional cues during tissue morphogenesis, and when corrupted, contributes to developmental disorders and cancer. The transmembrane protein Dispatched is an essential component of the machinery that deploys He...

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Bibliographic Details
Main Authors: Daniel P Stewart, Suresh Marada, William J Bodeen, Ashley Truong, Sadie Miki Sakurada, Tanushree Pandit, Shondra M Pruett-Miller, Stacey K Ogden
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
morphogen
signal transduction
Furin clevage
hedgehog
Dispatched
development
Online Access:https://elifesciences.org/articles/31678

Internet

https://elifesciences.org/articles/31678

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