Deferred Administration of Afobazole Induces Sigma1R-Dependent Restoration of Striatal Dopamine Content in a Mouse Model of Parkinson’s Disease

Deferred Administration of Afobazole Induces Sigma1R-Dependent Restoration of Striatal Dopamine Content in a Mouse Model of Parkinson’s Disease

Previously, we demonstrated that the immediate administration of multitarget anxiolytic afobazole slows down the progression of neuronal damage in a 6-hydroxidodamine (6-OHDA) model of Parkinson’s disease due to the activation of chaperone Sigma1R. The aim of the present study is to evaluate the the...

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Bibliographic Details
Main Authors: Ilya A. Kadnikov, Ekaterina R. Verbovaya, Dmitry N. Voronkov, Mikhail V. Voronin, Sergei B. Seredenin
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
chaperone Sigma1R
Parkinson’s disease
6-OHDA
dopamine
rotarod
tyrosine hydroxylase
Online Access:https://www.mdpi.com/1422-0067/21/20/7620

Internet

https://www.mdpi.com/1422-0067/21/20/7620

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