Modulation of T-bet and Eomes during Maturation of Peripheral Blood NK cells Does Not Depend on Licensing/Educating KIR

Modulation of T-bet and Eomes during Maturation of Peripheral Blood NK cells Does Not Depend on Licensing/Educating KIR

Peripheral NK cells upregulate T-bet and downregulate Eomes, the key transcription factors regulating NK cell maturation and function during the last maturation steps toward terminally differentiated effector cells. During this process, NK cells acquire killer immunoglobulin-like receptors (KIR) and...

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Bibliographic Details
Main Authors: Amandine Pradier, Federico Simonetta, Sophie Waldvogel, Carine Bosshard, Jean-Marie Tiercy, Eddy Roosnek
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Immunology
Subjects:
KIR
maturation
Licensing
NK cell
T-bet
Eomes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00299/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00299/full

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