Pilot investigation on the dose-dependent impact of irradiation on primary human alveolar osteoblasts in vitro

Abstract Radiotherapy of head and neck squamous cell carcinoma can lead to long-term complications like osteoradionecrosis, resulting in severe impairment of the jawbone. Current standard procedures require a 6-month wait after irradiation before dental reconstruction can begin. A comprehensive char...

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Bibliographic Details
Main Authors: Anna-Klara Amler, Domenic Schlauch, Selin Tüzüner, Alexander Thomas, Norbert Neckel, Ingeborg Tinhofer, Max Heiland, Roland Lauster, Lutz Kloke, Carmen Stromberger, Susanne Nahles
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-99323-8