TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis

Epigenetic regulators contribute to the modulation of adipose thermogenesis by sensing environmental cues and regulating gene expression in response. Here the authors report that a DNA demethylase TET1 mediates epigenetic changes to repress thermogenic genes in mouse adipose tissue.

Bibliographic Details
Main Authors: Sneha Damal Villivalam, Dongjoo You, Jinse Kim, Hee Woong Lim, Han Xiao, Pete-James H. Zushin, Yasuo Oguri, Pouya Amin, Sona Kang
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18054-y