TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis

Epigenetic regulators contribute to the modulation of adipose thermogenesis by sensing environmental cues and regulating gene expression in response. Here the authors report that a DNA demethylase TET1 mediates epigenetic changes to repress thermogenic genes in mouse adipose tissue.

Bibliographic Details
Main Authors:	Sneha Damal Villivalam, Dongjoo You, Jinse Kim, Hee Woong Lim, Han Xiao, Pete-James H. Zushin, Yasuo Oguri, Pouya Amin, Sona Kang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18054-y

id	doaj-4797aed5ec144f80886437b84bb7f261
record_format	Article
spelling	doaj-4797aed5ec144f80886437b84bb7f2612021-08-29T11:39:40ZengNature Publishing GroupNature Communications2041-17232020-08-0111111410.1038/s41467-020-18054-yTET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesisSneha Damal Villivalam0Dongjoo You1Jinse Kim2Hee Woong Lim3Han Xiao4Pete-James H. Zushin5Yasuo Oguri6Pouya Amin7Sona Kang8Nutritional Sciences and Toxicology Department, University of California BerkeleyNutritional Sciences and Toxicology Department, University of California BerkeleyNutritional Sciences and Toxicology Department, University of California BerkeleyDivision of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center Department of Pediatrics & Biomedical Informatics, University of CincinnatiNutritional Sciences and Toxicology Department, University of California BerkeleyNutritional Sciences and Toxicology Department, University of California BerkeleyUCSF Diabetes Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Cell and Tissue Biology, University of CaliforniaNutritional Sciences and Toxicology Department, University of California BerkeleyNutritional Sciences and Toxicology Department, University of California BerkeleyEpigenetic regulators contribute to the modulation of adipose thermogenesis by sensing environmental cues and regulating gene expression in response. Here the authors report that a DNA demethylase TET1 mediates epigenetic changes to repress thermogenic genes in mouse adipose tissue.https://doi.org/10.1038/s41467-020-18054-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sneha Damal Villivalam Dongjoo You Jinse Kim Hee Woong Lim Han Xiao Pete-James H. Zushin Yasuo Oguri Pouya Amin Sona Kang
spellingShingle	Sneha Damal Villivalam Dongjoo You Jinse Kim Hee Woong Lim Han Xiao Pete-James H. Zushin Yasuo Oguri Pouya Amin Sona Kang TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis Nature Communications
author_facet	Sneha Damal Villivalam Dongjoo You Jinse Kim Hee Woong Lim Han Xiao Pete-James H. Zushin Yasuo Oguri Pouya Amin Sona Kang
author_sort	Sneha Damal Villivalam
title	TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis
title_short	TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis
title_full	TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis
title_fullStr	TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis
title_full_unstemmed	TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis
title_sort	tet1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-08-01
description	Epigenetic regulators contribute to the modulation of adipose thermogenesis by sensing environmental cues and regulating gene expression in response. Here the authors report that a DNA demethylase TET1 mediates epigenetic changes to repress thermogenic genes in mouse adipose tissue.
url	https://doi.org/10.1038/s41467-020-18054-y
work_keys_str_mv	AT snehadamalvillivalam tet1isabeigeadipocyteselectiveepigeneticsuppressorofthermogenesis AT dongjooyou tet1isabeigeadipocyteselectiveepigeneticsuppressorofthermogenesis AT jinsekim tet1isabeigeadipocyteselectiveepigeneticsuppressorofthermogenesis AT heewoonglim tet1isabeigeadipocyteselectiveepigeneticsuppressorofthermogenesis AT hanxiao tet1isabeigeadipocyteselectiveepigeneticsuppressorofthermogenesis AT petejameshzushin tet1isabeigeadipocyteselectiveepigeneticsuppressorofthermogenesis AT yasuooguri tet1isabeigeadipocyteselectiveepigeneticsuppressorofthermogenesis AT pouyaamin tet1isabeigeadipocyteselectiveepigeneticsuppressorofthermogenesis AT sonakang tet1isabeigeadipocyteselectiveepigeneticsuppressorofthermogenesis
_version_	1721186570592059392

TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis

Similar Items