A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome

Summary: Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS), a genetic obesity syndrome characterized b...

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Bibliographic Details
Main Authors: Elena G. Bochukova, Katherine Lawler, Sophie Croizier, Julia M. Keogh, Nisha Patel, Garth Strohbehn, Kitty K. Lo, Jack Humphrey, Anita Hokken-Koelega, Layla Damen, Stephany Donze, Sebastien G. Bouret, Vincent Plagnol, I. Sadaf Farooqi
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718303474

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http://www.sciencedirect.com/science/article/pii/S2211124718303474

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