Genetic and Epigenetic Regulation of the Smoothened Gene (SMO) in Cancer Cells

Genetic and Epigenetic Regulation of the Smoothened Gene (SMO) in Cancer Cells

(1) Background: The hedgehog (HH) signaling pathway is a key regulator of embryonic patterning, tissue regeneration, stem cell renewal, and cancer growth. The smoothened (SMO) protein regulates the HH signaling pathway and has demonstrated oncogenic activity. (2) Methods: To clarify the role of the...

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Bibliographic Details
Main Authors: Hong Lou, Hongchuan Li, Andrew R. Huehn, Nadya I. Tarasova, Bahara Saleh, Stephen K. Anderson, Michael Dean
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
hedgehog pathway
smoothened
promoter
methylation
transcription factors
Online Access:https://www.mdpi.com/2072-6694/12/8/2219

Internet

https://www.mdpi.com/2072-6694/12/8/2219

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