Monitoring Cellular Movement with Photoconvertible Fluorescent Protein and Single-Cell RNA Sequencing Reveals Cutaneous Group 2 Innate Lymphoid Cell Subtypes, Circulating ILC2 and Skin-Resident ILC2

Monitoring Cellular Movement with Photoconvertible Fluorescent Protein and Single-Cell RNA Sequencing Reveals Cutaneous Group 2 Innate Lymphoid Cell Subtypes, Circulating ILC2 and Skin-Resident ILC2

We previously generated a transgenic mouse line expressing skin-specific IL-33 (IL33tg mice) and showed that IL-33 elicits group 2 innate lymphoid cell (ILC2)–dependent atopic dermatitis–like skin inflammation. ILC2s are believed to be tissue-resident cells under steady-state conditions, but the dyn...

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Bibliographic Details
Main Authors: Minori Nakatani-Kusakabe, Koubun Yasuda, Michio Tomura, Makoto Nagai, Kiyofumi Yamanishi, Etsushi Kuroda, Nobuo Kanazawa, Yasutomo Imai
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:JID Innovations
Online Access:http://www.sciencedirect.com/science/article/pii/S2667026721000357

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http://www.sciencedirect.com/science/article/pii/S2667026721000357

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