Non-Invasive Measurement of Drug and 2-HG Signals Using <sup>19</sup>F and <sup>1</sup>H MR Spectroscopy in Brain Tumors Treated with the Mutant IDH1 Inhibitor BAY1436032

Non-Invasive Measurement of Drug and 2-HG Signals Using <sup>19</sup>F and <sup>1</sup>H MR Spectroscopy in Brain Tumors Treated with the Mutant IDH1 Inhibitor BAY1436032

Background: BAY1436032 is a fluorine-containing inhibitor of the R132X-mutant isocitrate dehydrogenase (mIDH1). It inhibits the mIDH1-mediated production of 2-hydroxyglutarate (2-HG) in glioma cells. We investigated brain penetration of BAY1436032 and its effects using <sup>1</sup>H/<...

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Bibliographic Details
Main Authors: Katharina J. Wenger, Christian Richter, Michael C. Burger, Hans Urban, Stefan Kaulfuss, Patrick N. Harter, Sridhar Sreeramulu, Harald Schwalbe, Joachim P. Steinbach, Elke Hattingen, Oliver Bähr, Ulrich Pilatus
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
glioma
IDH mutation
2-hydroxyglutarate
murine model
targeted therapy
small molecule inhibitor
Online Access:https://www.mdpi.com/2072-6694/12/11/3175

Internet

https://www.mdpi.com/2072-6694/12/11/3175

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