Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate.

Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate.

Cleft lip with or without cleft palate (CL/P) is the most commonly occurring craniofacial birth defect. We provide insight into the genetic etiology of this birth defect by performing genome-wide association studies in two species: dogs and humans. In the dog, a genome-wide association study of 7 CL...

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Bibliographic Details
Main Authors: Zena T Wolf, Harrison A Brand, John R Shaffer, Elizabeth J Leslie, Boaz Arzi, Cali E Willet, Timothy C Cox, Toby McHenry, Nicole Narayan, Eleanor Feingold, Xioajing Wang, Saundra Sliskovic, Nili Karmi, Noa Safra, Carla Sanchez, Frederic W B Deleyiannis, Jeffrey C Murray, Claire M Wade, Mary L Marazita, Danika L Bannasch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4370697?pdf=render

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http://europepmc.org/articles/PMC4370697?pdf=render

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