Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate.
Cleft lip with or without cleft palate (CL/P) is the most commonly occurring craniofacial birth defect. We provide insight into the genetic etiology of this birth defect by performing genome-wide association studies in two species: dogs and humans. In the dog, a genome-wide association study of 7 CL...
Main Authors: | Zena T Wolf, Harrison A Brand, John R Shaffer, Elizabeth J Leslie, Boaz Arzi, Cali E Willet, Timothy C Cox, Toby McHenry, Nicole Narayan, Eleanor Feingold, Xioajing Wang, Saundra Sliskovic, Nili Karmi, Noa Safra, Carla Sanchez, Frederic W B Deleyiannis, Jeffrey C Murray, Claire M Wade, Mary L Marazita, Danika L Bannasch |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-03-01
|
Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4370697?pdf=render |
Similar Items
-
A LINE-1 insertion in DLX6 is responsible for cleft palate and mandibular abnormalities in a canine model of Pierre Robin sequence.
by: Zena T Wolf, et al.
Published: (2014-04-01) -
Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog.
by: Danika Bannasch, et al.
Published: (2008-11-01) -
The role of ADAMTS-4 and ADAMTS-1 in angiogenesis
by: Hsu, Yi-Ping
Published: (2012) -
Genome-Wide Association Study of Non-syndromic Orofacial Clefts in a Multiethnic Sample of Families and Controls Identifies Novel Regions
by: Nandita Mukhopadhyay, et al.
Published: (2021-04-01) -
The ADAMTS/Fibrillin Connection: Insights into the Biological Functions of ADAMTS10 and ADAMTS17 and Their Respective Sister Proteases
by: Stylianos Z. Karoulias, et al.
Published: (2020-04-01)