BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives

BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives

The Kirsten rat sarcoma viral oncogene homolog (RAS)/v-raf-1 murine leukemia viral oncogene homolog 1 (RAF)/mitogen-activated protein kinase 1 (MAPK) signaling cascade is the most important oncogenic pathway in human cancers. Tumors leading mutations in the gene encoding for v-raf murine sarcoma vir...

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Bibliographic Details
Main Authors: Fabiana Crispo, Tiziana Notarangelo, Michele Pietrafesa, Giacomo Lettini, Giovanni Storto, Alessandro Sgambato, Francesca Maddalena, Matteo Landriscina
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
BRAF mutation
thyroid cancer
BRAF inhibitors
mechanism of resistance
Online Access:https://www.mdpi.com/2072-6694/11/9/1388

Internet

https://www.mdpi.com/2072-6694/11/9/1388

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