IL-6 and IL-8 secreted by tumour cells impair the function of NK cells via the STAT3 pathway in oesophageal squamous cell carcinoma

IL-6 and IL-8 secreted by tumour cells impair the function of NK cells via the STAT3 pathway in oesophageal squamous cell carcinoma

Abstract Background Recurrence and metastasis are the leading causes of tumour-related death in patients with oesophageal squamous cell carcinoma (ESCC). Tumour-infiltrating natural killer cells (NK cells) display powerful cytotoxicity to tumour cells and play a pivotal role in tumour therapy. Howev...

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Bibliographic Details
Main Authors: Jian Wu, Feng-xia Gao, Chao Wang, Mei Qin, Fei Han, Tao Xu, Zhi Hu, Yang Long, Xue-mei He, Xin Deng, De-lian Ren, Tian-yang Dai
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Nature killer cell
IL-6
IL-8
STAT3 signalling
Oesophageal squamous cell carcinoma
Online Access:http://link.springer.com/article/10.1186/s13046-019-1310-0

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http://link.springer.com/article/10.1186/s13046-019-1310-0

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