RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.

Huntington's Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we present a genome-wide analys...

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Bibliographic Details
Main Authors: Adam Labadorf, Andrew G Hoss, Valentina Lagomarsino, Jeanne C Latourelle, Tiffany C Hadzi, Joli Bregu, Marcy E MacDonald, James F Gusella, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, Richard H Myers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4670106?pdf=render

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http://europepmc.org/articles/PMC4670106?pdf=render

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