A diverse repertoire of CD4 T cells targets the immediate-early 1 protein of human cytomegalovirus

A diverse repertoire of CD4 T cells targets the immediate-early 1 protein of human cytomegalovirus

T cell responses to the immediate-early 1 (IE-1) protein of human cytomegalovirus (HCMV) are associated with protection from viral disease. Thus, IE-1 is a promising target for immunotherapy. CD8 T cell responses to IE-1 are generally strong. In contrast, CD4 T cell responses to IE-1 were described...

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Bibliographic Details
Main Authors: Stefanie eAmeres, Xiaoling eLiang, Martina eWiesner, Josef eMautner, Andreas eMoosmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Immunology
Subjects:
Cytomegalovirus
HLA-DR
hcmv
CD4 T cells
HLA-DQ
HLA class II
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00598/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00598/full

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