Combined Pharmacological Inhibition of Cyclophilins, FK506-Binding Proteins, Hsp90, and Hsp70 Protects Cells From Clostridium botulinum C2 Toxin

Combined Pharmacological Inhibition of Cyclophilins, FK506-Binding Proteins, Hsp90, and Hsp70 Protects Cells From Clostridium botulinum C2 Toxin

The Clostridium botulinum C2 toxin is an exotoxin causing severe enterotoxic symptoms. The C2 toxin consists of the binding/translocation component C2II, and the enzymatic active component C2I. After proteolytic activation, C2IIa forms heptamers that bind C2I. The C2IIa/C2I complex is taken up into...

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Bibliographic Details
Main Authors: Katharina Ernst, Carolin Kling, Marc Landenberger, Holger Barth
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
bacterial protein toxin
PPIases
cyclophilins
FK506 binding proteins
chaperones
membrane translocation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01287/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01287/full

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